In this regard, a four-week supplementation of RES in a clinical trial of subjects with T2DM and coronary heart disease showed beneficial effects on glycemic control, HDL cholesterol levels, total/HDL cholesterol ratio, TAC and MDA levels, along with an upregulation of PPAR-γ and SIRT1 in the PBMCs of T2DM patients with coronary disease [287]. The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.