A recent study revealed high prevalence of DICER1 mutations in pediatric-adolescent poorly differentiated thyroid cancer (83%) at a hotspot in the metal-ion binding sites of the RNase IIIb domain of DICER1 (c.5113G>A, p.E1705K, c.5125G>A, p.D1709N (rs1595331264), c.5137G>A, p.1713Y, c.5437G>A, p.E1813K, c.5437G>C, p.E1813Q) [79]. Here, DICER1 is linked to poorly differentiated thyroid gland carcinoma.