Table 1 presents the exact results of laboratory tests for two SSc patients with ischemic maculopathy (SSc patients 1 and 2) and for both tested groups. Table 2 shows the calculations for coefficients of parameters. In the Table S1 we included the calculation of TIMP, MMP, VEGF, and sVEGFR-2 molecular weights for stoichiometric analysis. This evidence concerns the gene TIMP1 and systemic sclerosis.