Because resveratrol has multiple biological functions not just an AhR antagonist, whereas not all tryptophan-derived metabolites are AhR ligands, additional studies are required to elucidate which metabolite(s)-induced hypertension and kidney disease is AhR-dependent and develop a specific AhR-targeting approach as a reprogramming intervention in the future. The gene discussed is AHR; the disease is Hypertension.