We have previously shown that administering the SGLT2 inhibitor, Dapagliflozin, to either C57Bl/6 mice or hypertensive BPH/2J mice on a high fat diet reduces SNS innervation and activation in the kidneys and the heart, in addition to reducing weight gain [14,15]. The gene discussed is SLC5A2; the disease is benign prostatic hyperplasia.