The NCATS OpenData portal, which was developed to provide insight into drug repurposing for the treatment of COVID-19 (https://opendata.ncats.nih.gov/covid19) [26], provides drug results that affect protein–protein interaction between ACE2 and RBD (Receptor-binding domain) of the SARS-CoV-2 S protein through AlphaLISA and TruHit (counterscreen) ACE2-Spike protein–protein interaction proximity assay. This evidence concerns the gene PROS1 and COVID-19.