CD34 and central nervous system cancer: Figure 6a shows highly cellular tumors with pleomorphism and zones of coagulative necrosis lined by palisading neoplastic cells, and Figure 6b shows a complex form of microvascular hyperplasia with peri-endothelial growth patterns. Another characteristic feature of the C6 glioma model is shown in Figure 6c,d, in which tissue sections of tumors stained with an anti-CD34 antibody, used to identify microvessels and quantify MVD, show increased MVD at the periphery of necrotic areas.