MYC and cancer: MYC is a potent oncogene that alone can reactivate the embryonic stem cell-like program in normal and cancer cells [29,33,51,52,53,54,55] that is overexpressed by various mechanisms in more than half of breast cancers [33,56,57,58,59]; and functionally, MYC indeed contributes to tumor initiation and progression in breast cancer [33,34,60].