Examination of nine sarcomeric and cytoskeletal genes across 20 cancer types showed that uterine cancers harbored the greatest rates of amplification and overexpression of the γ-actin gene, ACTG1. Two of the three actin genes that we analyzed in this report, ACTA1 (α-skeletal) and ACTC1 (α-cardiac) are primarily found in muscle cells, whereas ACTG1 is ubiquitously and highly expressed in non-muscle cells [30]. Here, ACTC1 is linked to cancer.