Although of distinct histology and pathogenesis, uterine corpus endometrial carcinomas (UCEC), which includes multiple subtypes, the majority being uterine endometrioid carcinoma (UEC) as well as uterine serous carcinoma (USC) and uterine mixed endometrial carcinoma (UMEC), also upregulated ACTG1 and MYLK2 (Figure 1B,C). The gene discussed is ACTG1; the disease is uterine corpus endometrial carcinoma.