This frequency was also shown to be comparable to previously known oncogenes, KRAS and PIK3CA. Among 21 cancer lineages with ACTG1 dependent cell lines, 4 lineages had more than half the cell lines score as ACTG1 dependent; 58% of endometrial/uterine cancer cell lines; 55% of ovarian cancer cell lines; 52% of head and neck cancer cell lines; and 52% of colon/colorectal cancer cell lines (Figure 6C). The gene discussed is PIK3CA; the disease is cancer.