Intriguingly, our studies revealed that the UMUC-3 and T24 bladder cancer cells with Kras and Hras mutations were highly sensitive to FL118 treatment; in contrast, HT1376 cells without Ras mutation showed resistance to FL118 in the cancer cell viability assay after FL118 treatment (Figure 1). The gene discussed is HRAS; the disease is urinary bladder carcinoma.