Our in vitro experimental data demonstrated that HT1376 bladder cancer cells are highly resistant to FL118 treatment, while UMUC-3 bladder cancer cells are highly sensitive to FL118 treatment in terms of (1) cell growth/viability inhibition (Figure 1, Figure S1), (2) apoptosis induction (Figure 2, Figure S2), (3) anti-apoptotic protein inhibition (Figure 3, Figure S3), (4) the role of Kras status (Figure 6, Figure S6) and (5) ROS production (Figure 7). Here, KRAS is linked to urinary bladder cancer.