Specifically, while cIAP2 did not show significant inhibition by FL118 in any of these three cell lines (HT1376, T24, UMUC3), FL118 treatment strongly inhibited the expression of survivin, XIAP and Mcl-1 in UMUC3 cells (Figure 3C, Figure S3C), and inhibited survivin and XIAP in T24 bladder cancer cells (Figure 3B, Figure S3B). Here, BIRC3 is linked to urinary bladder cancer.