In a mouse model of AD, curcumin decreased the levels of inflammatory molecules, such as IL1β, TNF-α, cyclooxygenase 2 (COX 2) and nitric oxide (NO), while also decreasing the number of glial fibrillary acidic protein-(GFAP) and Iba-1-positive cells, thus suppressing the neuroinflammatory response [52]. The gene discussed is GFAP; the disease is Alzheimer disease.