In a rat MS model, curcumin increased the level of myelination by potentiating protective pathways against oxidative stress, the Nrf2 pathway, by restoring iNOS mRNA levels and by enhancing brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), platelet-derived growth factor receptor α (PDGFR α), nestin (a neural stem cell marker), myelin basic protein (MBP), Olig2, and oligodendrocyte progenitor markers [76]. The gene discussed is BDNF; the disease is myeloid sarcoma.