PMEL and neoplasm: This bispecific ImmTAC molecule comprises an affinity-optimized T-cell Receptor (TCR) domain that recognizes Human Leukocyte Antigen (HLA)-gp100peptide complex on tumor cells, and an anti-CD3 scFv that binds CD3 on T-cells to re-direct and activate the T-cells to lyse the gp100 positive tumor cells.