TYK2 and cancer: To evaluate if IST5 affects kinase activity in cancer cells, we tested kinase inhibitory activity of IST5 in two custom-tailored panels including 54 relevant kinases (Table 1), including Jak1, Jak2, Jak3, Tyk2, Abl1, Abl2, Lck, Fyn, Src and TrkB/C.