MEG3 and neoplasm: Indeed, the chromosome alterations affecting the H19, KCNQ1OT1, PLAGL1 and GNAS DMRs also affected one or more WT driver genes in all analyzed cases, and the chromosome variants affecting the MEST, GRB10 and MEG3 DMRs also affected tumor driver genes in at least 83% of cases (Figure 5B, Table 1).