Finally, in roughly 40% of WT cases, the maternal 11p15.5 region is lost and the paternal counterpart is duplicated in the tumor cells, a mechanism known as uniparental disomy (UPD); as a consequence, the tumor DNA shows both gain of H19/IGF2:IG-DMR methylation and loss of KCNQ10T1:TSS-DMR methylation [1]. This evidence concerns the gene H19 and neoplasm.