This task can be achieved with the transcription factors, octamer-binding transcription factor 4 (Oct4), Krüppel-like factor 4 (Klf4), Sex determining region Y-box2 (Sox2) and oncogene of myelomatosis (c-Myc) (OKSM), which have been recognized for preserving the pluripotency of a staminal cell [206,207]. This evidence concerns the gene KLF4 and plasma cell myeloma.