BCL2 and colonic neoplasm: On the other hand, 40 μM luteolin induced ROS production, membrane permeabilization, a drop in ∆Ψm, and downregulation of the bcl-2 family of proteins in in vitro models of glioblastoma, triggering the release of Cyt c into the cytosol and activating the apoptotic pathway, as also observed in colon cancer cells (HT29) [51].