BDNF and depressive disorder: Shexiang Baoxin pill has been verified for anti-depression through inhibiting hypothalamic-pituitary-adrenal (HPA) axis hyperfunction, regulating the release of monoamine neurotransmitters and promoting the secretion of neurotrophins.[19] Noteworthy, as a medicine for treating heart disease, Shexiang Baoxin Pill may be especially appropriate for patients comorbid with cardiac conditions and depressive disorder.