VWF and hyperthyroidism: The effects of these changes in coagulability range from subclinical to fatal coagulative events.3 There is no current consensus on the pathophysiology of this hypercoagulability as numerous studies have shown a wide effect of hyperthyroidism on platelets, coagulations factors, and von Willebrand factor.4,5 However, a variety of data demonstrates that increased levels of thyroid hormone alter the coagulation-fibrinolysis equilibrium and this increase in hormone level is an independent risk factor for VTE.3,5–6