On the other hand, in an obesity‐related decrease in SHBG concentrations (27.6 vs. 55.4 nmol/L, P = 0.037), total LNG AUC would decrease by ~ 1.7‐fold in obese women (P value < 0.01).14 The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.