For all SSc patients, the appropriate screening tools include the 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) echocardiographic recommendations (Figure 2), and a combination of a FVC/DLCO > 1.6 and a N‐terminal pro‐BNP > 2 times upper limit of normal. The gene discussed is NPPB; the disease is systemic sclerosis.