Follow-up assessment of baseline biopsies from all expansion cohort patients with low tumor MGMT expression revealed robust expression of MLH1, MSH2, MSH6, and PMS2 proteins in 5 of 5 cases (data not shown), likely indicating a functional MMR response; however, the assay results were not informative regarding the patient response to treatment on this study. The gene discussed is MLH1; the disease is neoplasm.