IL2 and melanoma: Fusion proteins based on the L19 antibody (specific to the alternatively-spliced extra-domain B (EDB) of fibronectin, a marker of angiogenesis) and on IL2 or TNF are being investigated in Phase III clinical trials for the treatment of patients with melanoma (https://clinicaltrials.gov/ NCT02938299, EudraCT 2015–002549-72) or with soft-tissue sarcoma (https://clinicaltrials.gov/ NCT03420014, EudraCT 2016-003239-38) [41].