For certain cytokines (such as IL2, IL12 and TNF) the fusion with a tumor-homing antibody allows the creation of novel biopharmaceuticals, which display a preferential uptake in tumor lesions and which perform substantially better than the corresponding nontargeted cytokine in immunocompetent mouse models [50, 51, 64, 65]. The gene discussed is IL2; the disease is neoplasm.