The translocation and hypermutation of BCL-6 at chromosome 3q27 with t(3;7) (q27;p12), translocations have been reported in 30–35% of DLBCL cases (Figure 1) and is a known event associated with the longer survival of malignant genetically unstable transformations associated with DLBCL [47]. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.