The main identifying feature of ABC-DLBCLs is a constitutive expression of the NF-κB signaling pathway due to aberrations in the components of the CBM signaling complex, which consists of caspase recruitment domain 11 (CARD11), BCL10, and MALT1, and which promotes proliferation, cell survival, and inhibition of tumor cell apoptosis [22]. This evidence concerns the gene NFKB1 and neoplasm.