In many tumors such as DLBCL, MDM2 overexpression is not solely caused by gene amplification, but is also indirectly associated with an increased affinity for the transcriptional activator SP1 (Figure 1), the binding of which results in elevated MDM2 expression in a gender-specific (females) and hormonal-dependent manner [100]. This evidence concerns the gene SP1 and diffuse large B-cell lymphoma.