Furthermore, an analysis of SNP309 in 108 patients treated with R-CHOP showed that, although the presence of the SNP did not correlate with poorer survival in DLBCL patients, p53 or MDM2 overexpression correlated with significantly worse survival when MUT-p53 was present [100, 101, 104]. This evidence concerns the gene DDIT3 and diffuse large B-cell lymphoma.