Increased NF-κB activity in ABC-DLBCL is stimulated by mutations in CARD11, a part of the CBM complex (CARD11, BCL-10, and MALT1), which acts as a signaling hub for activation of the classic NF-κB pathway downstream of the antigen receptors in B and T cells (Figure 2) [97, 98]. The gene discussed is MALT1; the disease is diffuse large B-cell lymphoma.