Among males, those in the highest quartile of ALT (Q4, ≥20 IU/L) were younger, less likely to have hypertension, albuminuria, and insulin resistance, and had lower proportions of self-reported cardiovascular complications (MI, stroke, CHF) compared to those in the lowest quartile (Q1, <12 IU/L); however, males in Q4 had higher BMI, lower HDL, and higher triglyceride levels compared to males in Q1. This evidence concerns the gene GPT and Insulin resistance.