SCN9A and epilepsy: The SCN9A variants identified as potentially pathogenic subsequent to p.(Asn641Tyr), include a number ([p.(Gln10Arg), p.(Ser490Asn), p.(Lys655Arg), p.(Ile739Val)]) which are present at population allele frequencies inconsistent with them being causative of a monogenic seizure disorder (Table 1 and S1 Table).