Results showed that the expression of OSM in the CCA patient tissues showed strong correlation with CTLA4 (cor=0.33, p=0.049), HAVCR2 (cor=0.45, p=0.006), PDL1 (cor=0.43, p=0.009) in OSM-dependent manner (Table 5, Figure 7B), * means p≤0.05. This evidence concerns the gene HAVCR2 and cholangiocarcinoma.