We found that Cl- channel inhibition blocked IL-1β release in a NLRP3-dependent model of peritonitis, and previously reported protective effects of the fenamate NSAIDs in rodent models of Alzheimer’s disease that we attributed to an effect on Cl- channel inhibition (Daniels et al., 2016). This evidence concerns the gene IL1B and early-onset autosomal dominant Alzheimer disease.