ApoE-/- mice (n = 9) developed extensive aortic aneurysm after 4 weeks of AngII-infusion as described previously including infiltration of inflammatory cells and ECM remodeling.14 Using the elastin-specific probe, a strong expression of elastin within the aortic wall could be observed in vivo in these mice due to a strong remodeling of the extracellular matrix (ECM) especially in the areas of former elastic fiber dissection. This evidence concerns the gene APOE and aortic aneurysm.