Onset of arthritis before pulmonary manifestation; trabecular bone loss and deterioration; bronchiolar and alveolar inflammation infiltration: neutrophils and exudative macrophages; collagen deposition, high levels of pentraxin‐2, anti‐CCP IgG, anti‐CII IgG, amphiregulin, anti‐MAA IgG antibody, immunoglobulin (IgG, IgM, IgA), TNF‐α, IL‐6, CXCL1, and CXCL2. The gene discussed is TNF; the disease is Arthritis.