Onset of arthritis before pulmonary manifestation; trabecular bone loss and deterioration; bronchiolar and alveolar inflammation infiltration: neutrophils and exudative macrophages; collagen deposition, high levels of pentraxin‐2, anti‐CCP IgG, anti‐CII IgG, amphiregulin, anti‐MAA IgG antibody, immunoglobulin (IgG, IgM, IgA), TNF‐α, IL‐6, CXCL1, and CXCL2. Here, CD40LG is linked to arthritic joint disease.