Onset of arthritis before pulmonary manifestation; trabecular bone loss and deterioration; bronchiolar and alveolar inflammation infiltration: neutrophils and exudative macrophages; collagen deposition, high levels of pentraxin‐2, anti‐CCP IgG, anti‐CII IgG, amphiregulin, anti‐MAA IgG antibody, immunoglobulin (IgG, IgM, IgA), TNF‐α, IL‐6, CXCL1, and CXCL2. This evidence concerns the gene AREG and arthritic joint disease.