Although prior studies have investigated changes in the expression of TSPO in HIV, encephalitis, Alzheimer's disease, multiple sclerosis, and stroke (Cosenza‐Nashat et al., 2009; Gui et al., 2020), no transcriptome studies of the human alcohol‐dependent brain reported find differences in TSPO expression levels (Brenner et al., 2020 May 8; Farris et al., 2015; Kapoor et al., 2019; Ponomarev et al., 2012). This evidence concerns the gene TSPO and multiple sclerosis.