However, segmental amplifications of 4q including PDGFRA, often associated with a concomitant loss of larger parts of 4q, were observed with a similar frequency in PMMRDIA (30%) and conventional supratentorial IDH-mutant high-grade astrocytomas (35%, Fig. 4). The gene discussed is PDGFRA; the disease is astrocytoma (excluding glioblastoma).