Consistent with our model, we previously reported the association of increased cerebrospinal fluid levels of oxidized phosphatidylcholine (a marker associated with oxidative stress) with induction treatment and consolidation among survivors of ALL treated with chemotherapy only.10 These increased levels were associated with neurocognitive deficits in working memory, organization, and attention.11 We suggested that neural networks rich in glucocorticoid receptors may be particularly at risk of damage from methotrexate and glucocorticoid exposure in survivors of ALL. Here, NR3C1 is linked to acute lymphoblastic leukemia.