In the DM + NS group, the levels of MDA (P < .05, 4.86 ± 4.74 nmol/mg protein), TNF‐α (P < .01, 26.35 ± 10.41 pg/mg protein), IL‐1β (P < .01, 48.42 ± 28.13 pg/mg protein), and IL‐6 (P < .01, 228.39 ± 58.29 pg/mg protein) were significantly increased as compared to that in the Non‐DM + NS group (1.65 ± 1.42 nmol/mg protein; 9.68 ± 2.93 pg/mg protein; 11.89 ± 6.97 pg/mg protein; and 121.43 ± 17.46 pg/mg protein, respectively). This evidence concerns the gene TNF and diabetes mellitus.