Furthermore, the DM + EDR (10 mg/kg) group showed a significant decrease in the upregulated levels of TNF‐α (P < .01, 12.45 ± 7.12 pg/mg protein), IL‐1β (P < .05, 24.54 ± 15.66 pg/mg protein), and IL‐6 (P < .05, 165.83 ± 35.37 pg/mg protein) compared with the DM + NS group. This evidence concerns the gene TNF and diabetes mellitus.