Based on the ceRNA hypothesis, we predicted six upstream lncRNAs (SNHG3, NUTM2B‐AS1, LINC00346, SNHG20, LINC00909 and TUG1), which were remarkably up‐regulated in HCC and associated with poor prognosis of HCC. The gene discussed is SNHG3; the disease is hepatocellular carcinoma.