The pivotal link between SARS-CoV-2 and downregulation of angiotensin-converting enzyme-2 in people with multiple comorbidities especially diabetes and hypertension may be a critical role in the overproduction of pro-inflammatory cytokines and COVID-19 severity.6 In addition to the relationship between older age and comorbidities, people in poor communities are less likely to have access to health care and social protection, and live in crowded homes with inadequate sanitation and hygiene, which increase the risk for COVID-19 transmission and death.2 The gene discussed is ACE2; the disease is COVID-19.