MAPT and Alzheimer disease: It should be noted that in bivariate models, nearly all variables (except for sex) were associated with tau PET positivity, with the directionality of these associations always in line with AD risk factors (i.e., older age, APOE ε4 positivity, lower MMSE, reduced AD-signature cortical thickness, and elevated global white matter hyperintensity volumes), but these associations did not survive in multivariable models accounting for Aβ status.