In the temporal meta-ROI, tau PET positivity was observed in 1.5% of Aβ-negative CU, 2.2% of Aβ-negative non-AD, 14.7% of Aβ-positive CU, 27.7% of Aβ-positive non-AD, 46.5% of Aβ-positive MCI, and 88.6% of Aβ-positive AD dementia. This evidence concerns the gene MAPT and Alzheimer disease.