Spleen tyrosine kinase (SYK) performs a key role upstream of caspase-1 and caspase-8, primarily upregulating NF-κB and IL-1β signaling in Pstpip2cmo mice, and induction of chronic multifocal osteomyelitis (CMO). This evidence concerns the gene NFKB1 and chronic recurrent multifocal osteomyelitis.