PDCD1, PDCD1LG2 are the key targets in the treatment of widely used PD-1/PD-L1 inhibitors and plays an important role in adolescent idiopathic arthritis, diffuse large B-cell lymphoma, head and neck squamous cell carcinoma, colorectal cancer and other diseases (32–36). Here, PDCD1LG2 is linked to head and neck squamous cell carcinoma.