Previous studies on oral cancer have shown that the four genes namely CALM3, ARRB1, HTT, and FLNA were involved in a carcinogenesis pathway [9].Among these the CALM3 gene or the protein Calmodulin is a critical molecule that plays an important role in calcium-dependent signaling for various physiological processes within thecell [10]. The gene discussed is CALM3; the disease is lip and oral cavity carcinoma.