In a study of normokalemic patients with hypertension who were randomly assigned to treatment with the ACE inhibitor lisinopril, the diuretic chlorthalidone, or the CCB amlodipine, the incidence of hyperkalemia was found to be greater in the patients treated with lisinopril (3.6%) than in those treated with either of the other agents (p < 0.01 for both) [85]. This evidence concerns the gene ACE and hypertensive disorder.