Approaches to managing hyperkalemia depend upon symptom severity and include dietary potassium intake restriction, dosage adjustment of MR blockers and/or RAS inhibitors, promotion of potassium excretion from the body using diuretics, use of oral potassium adsorbent agents, such as calcium/sodium polystyrene sulfonate, promotion of potassium redistribution from extracellular to intracellular spaces via intravenous administration of insulin and glucose, cell membrane stabilization via intravenous administration of calcium solution, and hemodialysis [118–120]. Here, NR3C2 is linked to Hyperkalemia.