Also the omental samples (available from the 12 patients with obesity) showed positive correlations of PRRX1 and COL6A3 mRNA (SVF: p = 8.66E-5, r = 0.894; adipocytes: p = 0.263, r = 0.335, data now shown). This evidence concerns the gene COL6A3 and obesity due to melanocortin 4 receptor deficiency.