COL6A3 and obesity due to melanocortin 4 receptor deficiency: Thus, to probe for potential transcriptional regulators of COL6A3, we correlated COL6A3 mRNA with other mRNA transcripts in our previously published global transcriptome analysis of subcutaneous adipose tissue, which included 16 people with obesity before and after profound fat loss as well as 13 lean people17 (Cohort 1, Table 1).