M2b macrophages (IL10high IL12low CD86+ MHCII+), whose characteristics is between M1 classically activated macrophages with proinflammatory antitumoral function and M2 alternatively-activated macrophages and promote tumor growth and invasion, are induced by combined immune complexes as well as TLR or IL-1R agonists and produce IL1, IL6, IL10 and TNFα1,15,16. This evidence concerns the gene IL10 and neoplasm.