For instance, the high expression of RIG-I in ovarian cancer is correlated with higher tumor grade and poor outcome, as well as the higher expression of PD-L1 and the regulatory T cell-specific transcription factor FoxP3.166 In contrast, the low expression of RIG-I in hepatocellular carcinoma patients is positively correlated to short survival.167 Thus, the expression and the relevance of sensors in different tumor types should be considered in the combination of these sensor agonists with ICIs. The gene discussed is CD274; the disease is hepatocellular carcinoma.