And the increase of dsRNAs is detected via MDA5, which further induces IFN response to anti-tumor.124,125 In addition, 5-AZA-CdR treatment can potentiate the anti-tumor effect of anti-CTLA-4 antibody in the breast cancer mouse model, which may be associated with high viral defense.126. Here, IFNA1 is linked to breast carcinoma.