CD8A and melanoma: Poly-ICLC (Hiltonol) is a synthetic Poly-IC that can induce tumor specific NK cells, CTLs, and NK-T cell-mediated immune responses via activating TLR3 and MDA5.91,92 In addition, poly-ICLC was shown to be an effective adjuvant to prime antigen specific CD8+ T cells and prolong survival In murine models of glioma and melanoma.93 And various clinical studies have revealed the contributions of Poly-ICLC alongside tumor-specific antigens to improve immune responses.91,92,94