RIG-I like receptors (RLRs), including RIG-I, melanoma differentiation- associated protein 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2), are expressed in the cytosol of most immune and non-immune cells, including cancer cells.16 RLRs are common in sharing the DExD/H-box helicase domain and C-terminal domain(CTD), which are essential for the recognition of exogenous nuclear acids like viral RNAs. The gene discussed is IFIH1; the disease is cancer.