On the other side, the activation of RIG-I in cancer cells could induce the production of proinflammatory cytokines such as CXCL10, IL-6, IFNβand the upregulation of the MHC-I expression in cancer cells, which could stimulate DCs and subsequently activate cytotoxic T cells.30–33 In addition, activated RIG-I could recruit the inflammasome adapter ASC, which activates caspase-1. The gene discussed is IL6; the disease is cancer.