And the inflammasome sensors are usually divided into three classes: (1) Absent in melanoma 2 pyrin and hemopoietic expression, interferon-inducibility, nuclear localization, and characteristic 200 amino-acid domain (HIN200) containing protein (PYHIN) family, (2) nucleotide binding domain and leucine-rich repeats (NLR) containing protein family, (3) TRIM family member, Pyrin. The gene discussed is MEFV; the disease is melanoma.