Ras proteins (H-Ras, N-Ras, and K-Ras) are well known as the most commonly mutated oncoproteins in human cancer, with activating mutations found in approximately 20% of cancers and with higher incidences in pancreatic (88%), colorectal (55%) and lung cancers (33%) (1). The gene discussed is KRAS; the disease is lung carcinoma.