In this line, we previously reported the apoptotic activity of the two compounds; 3-(4-chlorophenyl)-5-(4-fluorophenyl)-4-phenyl-4,5-dihydro-1,2,4-oxadiazole (A) and 3,5-bis-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1,2,4-oxadiazole (B) (Fig. 1) in the breast cancer cells via a COX-2 independent pathway [18], although these compounds interacted with the active site of COX-2 enzyme [19]. Here, PTGS2 is linked to breast carcinoma.