PSEN2 and Alzheimer disease: Two novel significant associations with AD-Cm were observed: PSEN2-rs75733498 (OR 0.39 [0.23–0.63]; P = 1.8 × 10−4) and NME8-rs2722372 (β − 0.04 [− 0.06 to − 0.018]; P = 7.6 × 10−4) (Table 1; Fig. 2b; Supplementary Fig. S2b).