No rare variants were significantly associated with AD-Cm hypometabolism, but FERMT2 (OR 2.37 [1.07–5.61]; P = 0.02) and NFAT5 (OR 4.24 [1.15–23.32]; P = 0.02) showed significant enrichment for the presence of PCC hypometabolism (Table. The gene discussed is NFAT5; the disease is Alzheimer disease.