Voxel-wise analysis of PiB-PET consistently revealed that PIWIL1 variant carriers displayed greater levels of cerebral Aβ deposition as compared to non-carriers, and regional GM atrophy mainly in the bilateral temporal and PC-PCC areas and medial and inferior frontal regions, which were reported to be vulnerable to the AD process [19]. The gene discussed is PIWIL1; the disease is Alzheimer disease.