Importantly, in ovarian cancer, linc00092 maintains the local supportive function of CAFs by binding to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) to promote glycolysis in cancer cells, thus contributing to cancer metastasis [195]. Here, PFKFB2 is linked to ovarian carcinoma.