Transcriptomic comparisons between newly diagnosed SLE patients clustered by DAP1 genotype revealed several differences in their expression profiles for genes involved in the regulation of innate and adaptive immunity (ITGAM, SLAMF6), B and T cell activation (FCRLA, CD8B), the apoptotic pathway (CASP8AP2, CASP7), and autophagy (ATG5) (Fig. 4). Here, CASP8AP2 is linked to systemic lupus erythematosus.