FOXO3 and systemic lupus erythematosus: For example, expression levels of genes such as Integrin Subunit Alpha M (ITGAM) and Forkhead Box O3 (FOXO3), which have been previously shown to have decreased expression in SLE patients [11, 59, 60], were significantly further reduced in SLE patients carrying the DAP1 risk allele compared to the protective allele.