p53 neomorphic proteins [49, 69–71], associated to mutations in p53 sequence, were implicated in alteration of physiological cellular signalling, including the function of the p53 family members, p63 [72–76] and p73 [77–81] and other transcriptional factors, such as HIF-1 [82] in several different cancer types [83–85]. Here, TP53 is linked to cancer.