Taken together, these results demonstrate that the CXCL13/CXCR5/NFκB/p65 signaling pathway promotes the transcription of miR-934 in CRC cells, forming a positive feedback loop that is involved in persistent M2 macrophage polarization and in the invasion and metastasis of CRC cells. This evidence concerns the gene CXCR5 and colorectal carcinoma.