The expression of the M2 markers [17], (CD206, arginase-1, IL10, and CD163) was significantly increased in macrophages incubated with exosomes derived from CRC cells exhibiting high miR-934 expression compared to that in macrophages incubated with exosomes from cells exhibiting low miR-934 expression or cells incubated with PBS, while M1 markers (iNOS and IL-1β) showed almost no difference (Fig. 3f, g). Here, ARG1 is linked to colorectal carcinoma.