The CXCL13/CXCR5 axis promotes tumor progression through the PI3K/AKT/mTOR pathway, contributes to poor prognosis in clear cell renal cell carcinoma [38], and promotes the growth and invasion of colon cancer cells via the PI3K/AKT pathway [39]. The gene discussed is CXCR5; the disease is clear cell renal carcinoma.