CXCL12 and ovarian carcinoma: [24, 35] For example, exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced CRLM by enhancing M2 polarization of macrophages [24], and hypoxic epithelial ovarian cancer-derived exosomal miR-940 promotes epithelial ovarian cancer proliferation and migration by inducing M2 polarization of macrophages [35].