In the present study, we demonstrated that the M2 polarization of macrophages induced by CRC cell-derived exosomal miR-934 could promote CRLM via a CXCL13/CXCR5/NFκB/p65 positive feedback loop, which resulted in persistent crosstalk between tumor cells and TAMs, forming an inflammatory microenvironment to foster CRLM. This evidence concerns the gene CXCL13 and neoplasm.